Search results for "Lymphotoxin alpha"
showing 2 items of 2 documents
Acute Effects of Tumor Necrosis Factor-α or Lymphotoxin on Oxygenation and Bioenergetic Status in Experimental Tumors
1994
Recombinant human tumor necrosis factor-α (rhTNF-α) exerts direct cytolytic and cytostatic effects on tumor cells in vitro (Fiers,1991).In vivo,indirect actions on the tumor microvasculature have been described, such as the formation of fibrin thrombi (Nawroth et al.,1988),which cause stasis and damage of tumor microvessels with subsequent hemorrhagic necrosis.
Tumor necrosis factor (TNF) and lymphotoxin-a (LTA) polymorphisms and risk of non-hodgkin lymphoma in the interLymph consortium
2010
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-…